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elranatamab will boost the level or influence of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Elranatamab causes cytokine launch syndrome (CRS) that could suppress exercise of CYP enzymes, leading to amplified publicity of CYP substrates.brimonidine and fentanyl transdermal both raise sedation.